| Implant, Endosseous, Root-Form | 3,864,627 | 44 | 3,833,903 | 1993–2026 |
| Integrated Continuous Glucose Monitoring System, Factory Calibrated | 2,174,195 | 226 | 40,360 | 2007–2026 |
| Pump, Infusion | 1,827,009 | 1,751 | 24,185 | 1991–2026 |
| Alternate Controller Enabled Insulin Infusion Pump | 1,260,826 | 319 | 138,643 | 2020–2026 |
| Pump, Infusion, Insulin, To Be Used With Invasive Glucose Sensor | 890,539 | 2,249 | 126,552 | 2004–2026 |
| Automated Insulin Dosing Device System, Single Hormonal Control | 885,752 | 1,254 | 127,210 | 2015–2026 |
| Pump, Infusion, Insulin | 539,077 | 1,411 | 96,050 | 1992–2026 |
| Automated Insulin Dosing , Threshold Suspend | 439,398 | 1,532 | 90,673 | 2014–2026 |
| System, Test, Blood Glucose, Over The Counter | 431,358 | 116 | 37,934 | 1999–2026 |
| Implantable Cardioverter Defibrillator (Non-Crt) | 379,353 | 10,094 | 226,424 | 1992–2026 |
| Stimulator, Spinal-Cord, Totally Implanted For Pain Relief | 375,710 | 1,904 | 270,266 | 1992–2026 |
| Permanent Pacemaker Electrode | 325,343 | 9,381 | 172,985 | 1992–2026 |
| Sensor, Glucose, Invasive, Non-Adjunctive | 324,715 | 10 | 2,321 | 2016–2026 |
| Set, Administration, Intravascular | 309,977 | 779 | 58,059 | 1992–2026 |
| Ventilator, Non-Continuous (Respirator) | 300,898 | 4,569 | 53,622 | 1993–2026 |
| Sensor, Glucose, Invasive | 281,941 | 321 | 13,632 | 1992–2026 |
| Automated External Defibrillators (Non-Wearable) | 268,697 | 4,510 | 1,937 | 1992–2026 |
| Prosthesis, Breast, Noninflatable, Internal, Silicone Gel-Filled | 229,178 | 137 | 223,823 | 1992–2026 |
| Drug Eluting Permanent Right Ventricular (Rv) Or Right Atrial (Ra) Pacemaker Electrodes | 228,094 | 5,055 | 128,126 | 1997–2026 |
| Ventilator, Continuous, Facility Use | 212,024 | 2,253 | 14,388 | 1991–2026 |
| Mesh, Surgical, Polymeric | 170,120 | 852 | 164,116 | 1992–2026 |
| Staple, Implantable | 169,612 | 1,100 | 31,855 | 1993–2026 |
| Defibrillator, Automatic Implantable Cardioverter, With Cardiac Resynchronization (Crt-D) | 169,573 | 4,802 | 84,628 | 2000–2026 |
| Integrated Continuous Glucose Monitoring System, Factory Calibrated, Not For Use With Automated Insulin Delivery Systems | 165,468 | 29 | 41,805 | 2020–2026 |
| System, Peritoneal, Automatic Delivery | 164,500 | 3,434 | 19,534 | 1992–2026 |
| Prosthesis, Knee, Patellofemorotibial, Semi-Constrained, Cemented, Polymer/Metal/Polymer | 157,471 | 262 | 132,428 | 1992–2026 |
| Ventricular (Assist) Bypass | 157,431 | 23,004 | 76,224 | 1992–2026 |
| Implantable Pulse Generator, Pacemaker (Non-Crt) | 156,369 | 1,854 | 89,886 | 1992–2026 |
| Wearable Automated External Defibrillator | 148,775 | 3,738 | 36,281 | 2002–2026 |
| Prosthesis, Hip, Semi-Constrained (Metal Uncemented Acetabular Component) | 138,399 | 387 | 130,623 | 1992–2026 |
| System, Surgical, Computer Controlled Instrument | 137,980 | 777 | 10,886 | 2000–2026 |
| Permanent Defibrillator Electrodes | 137,720 | 3,081 | 77,809 | 1997–2026 |
| Coronary Drug-Eluting Stent | 128,715 | 11,230 | 62,169 | 2003–2026 |
| Device, Hemostasis, Vascular | 123,919 | 741 | 102,551 | 1996–2026 |
| Electrosurgical, Cutting & Coagulation & Accessories | 117,697 | 467 | 19,658 | 1992–2026 |
| Prosthesis, Breast, Inflatable, Internal, Saline | 117,618 | 75 | 111,856 | 1992–2026 |
| Sensor, Glucose, Invasive, Non-Adjunctive, Factory-Calibrated, User-Initiated | 117,148 | 13 | 17,413 | 2017–2026 |
| Pump, Infusion, Implanted, Programmable | 116,799 | 1,634 | 74,805 | 1992–2026 |
| Cabinet, Table And Tray, Anesthesia | 97,989 | 11 | 77 | 1992–2026 |
| Pulse Generator, Permanent, Implantable | 95,144 | 3,912 | 49,618 | 1997–2026 |
| Bed, Ac-Powered Adjustable Hospital | 93,774 | 647 | 1,861 | 1992–2026 |
| System, X-Ray, Fluoroscopic, Image-Intensified | 90,606 | 20 | 220 | 1992–2026 |
| Prosthesis, Hip, Semi-Constrained, Metal/Polymer, Porous Uncemented | 89,781 | 195 | 82,346 | 1992–2026 |
| Laparoscope, General & Plastic Surgery | 83,414 | 262 | 6,932 | 1992–2026 |
| Stimulator, Electrical, Implantable, For Incontinence | 82,555 | 80 | 40,196 | 1992–2026 |
| Orthopedic Manual Surgical Instrument | 81,214 | 55 | 7,525 | 1994–2026 |
| Intraocular Lens | 79,358 | 4 | 34,033 | 1992–2026 |
| Analyzer, Chemistry (Photometric, Discrete), For Clinical Use | 78,872 | 25 | 1,167 | 1996–2026 |
| Colonoscope And Accessories, Flexible/Rigid | 78,298 | 63 | 1,345 | 1992–2026 |
| Aortic Valve, Prosthesis, Percutaneously Delivered | 78,144 | 7,956 | 58,351 | 2004–2026 |