| Implant, Endosseous, Root-Form | 3,537,615 | 42 | 3,507,501 | 1993–2026 |
| Integrated Continuous Glucose Monitoring System, Factory Calibrated | 1,913,309 | 174 | 31,666 | 2018–2026 |
| Pump, Infusion | 1,803,616 | 1,709 | 23,875 | 1991–2026 |
| Alternate Controller Enabled Insulin Infusion Pump | 1,088,188 | 213 | 114,774 | 2020–2026 |
| Pump, Infusion, Insulin, To Be Used With Invasive Glucose Sensor | 886,701 | 2,248 | 126,522 | 2004–2026 |
| Automated Insulin Dosing Device System, Single Hormonal Control | 838,920 | 1,227 | 122,353 | 2015–2026 |
| Pump, Infusion, Insulin | 534,449 | 1,407 | 95,739 | 1992–2026 |
| Automated Insulin Dosing , Threshold Suspend | 438,789 | 1,530 | 90,580 | 2014–2026 |
| System, Test, Blood Glucose, Over The Counter | 429,427 | 113 | 37,830 | 1999–2026 |
| Implantable Cardioverter Defibrillator (Non-Crt) | 369,312 | 10,004 | 220,498 | 1992–2026 |
| Stimulator, Spinal-Cord, Totally Implanted For Pain Relief | 362,034 | 1,806 | 259,356 | 1992–2026 |
| Sensor, Glucose, Invasive, Non-Adjunctive | 316,062 | 10 | 2,301 | 2016–2026 |
| Permanent Pacemaker Electrode | 313,884 | 9,301 | 168,493 | 1992–2026 |
| Sensor, Glucose, Invasive | 280,884 | 320 | 13,594 | 1992–2026 |
| Ventilator, Non-Continuous (Respirator) | 265,078 | 4,544 | 53,547 | 1993–2026 |
| Automated External Defibrillators (Non-Wearable) | 263,821 | 4,461 | 1,871 | 1992–2026 |
| Drug Eluting Permanent Right Ventricular (Rv) Or Right Atrial (Ra) Pacemaker Electrodes | 218,060 | 4,956 | 122,406 | 1997–2026 |
| Prosthesis, Breast, Noninflatable, Internal, Silicone Gel-Filled | 214,814 | 135 | 209,684 | 1992–2026 |
| Set, Administration, Intravascular | 207,687 | 438 | 21,566 | 1992–2026 |
| Ventilator, Continuous, Facility Use | 205,183 | 2,221 | 14,273 | 1991–2026 |
| Mesh, Surgical, Polymeric | 168,757 | 808 | 162,908 | 1992–2026 |
| Defibrillator, Automatic Implantable Cardioverter, With Cardiac Resynchronization (Crt-D) | 164,952 | 4,732 | 82,793 | 2000–2026 |
| Staple, Implantable | 164,903 | 1,085 | 31,194 | 1993–2026 |
| System, Peritoneal, Automatic Delivery | 163,240 | 3,401 | 18,975 | 1992–2026 |
| Prosthesis, Knee, Patellofemorotibial, Semi-Constrained, Cemented, Polymer/Metal/Polymer | 153,958 | 259 | 129,193 | 1992–2026 |
| Ventricular (Assist) Bypass | 153,365 | 22,316 | 74,817 | 1992–2026 |
| Implantable Pulse Generator, Pacemaker (Non-Crt) | 147,576 | 1,816 | 86,175 | 1992–2026 |
| Integrated Continuous Glucose Monitoring System, Factory Calibrated, Not For Use With Automated Insulin Delivery Systems | 146,937 | 27 | 40,638 | 2020–2026 |
| Wearable Automated External Defibrillator | 143,491 | 3,639 | 34,722 | 2002–2026 |
| Prosthesis, Hip, Semi-Constrained (Metal Uncemented Acetabular Component) | 137,622 | 385 | 130,043 | 1992–2026 |
| Permanent Defibrillator Electrodes | 132,799 | 3,030 | 74,889 | 1997–2026 |
| Coronary Drug-Eluting Stent | 127,490 | 11,160 | 61,719 | 2003–2026 |
| Device, Hemostasis, Vascular | 121,291 | 730 | 101,970 | 1996–2026 |
| System, Surgical, Computer Controlled Instrument | 118,454 | 732 | 9,994 | 2000–2026 |
| Sensor, Glucose, Invasive, Non-Adjunctive, Factory-Calibrated, User-Initiated | 114,527 | 12 | 17,161 | 2017–2026 |
| Electrosurgical, Cutting & Coagulation & Accessories | 114,517 | 456 | 19,201 | 1992–2026 |
| Pump, Infusion, Implanted, Programmable | 114,088 | 1,628 | 73,723 | 1992–2026 |
| Prosthesis, Breast, Inflatable, Internal, Saline | 113,497 | 72 | 107,773 | 1992–2026 |
| Pulse Generator, Permanent, Implantable | 92,723 | 3,860 | 48,343 | 1997–2026 |
| Bed, Ac-Powered Adjustable Hospital | 92,389 | 638 | 1,831 | 1992–2026 |
| System, X-Ray, Fluoroscopic, Image-Intensified | 90,588 | 20 | 217 | 1992–2026 |
| Prosthesis, Hip, Semi-Constrained, Metal/Polymer, Porous Uncemented | 87,564 | 184 | 80,416 | 1992–2026 |
| Laparoscope, General & Plastic Surgery | 80,330 | 257 | 6,774 | 1992–2026 |
| Stimulator, Electrical, Implantable, For Incontinence | 79,738 | 80 | 38,635 | 1992–2026 |
| Orthopedic Manual Surgical Instrument | 78,848 | 55 | 7,436 | 1994–2026 |
| Intraocular Lens | 77,018 | 4 | 33,504 | 1992–2026 |
| Analyzer, Chemistry (Photometric, Discrete), For Clinical Use | 76,746 | 25 | 1,133 | 1996–2026 |
| Transcervical Contraceptive Tubal Occlusion Device | 74,358 | 134 | 72,710 | 1994–2026 |
| Glucose Dehydrogenase, Glucose | 73,910 | 33 | 5,130 | 1998–2026 |
| Implant, Cochlear | 72,793 | 68 | 40,649 | 1993–2026 |